15-year Danish Study Shows that Yaz, Yasmin and Ocella increase the Risk of Thrombotic Stroke

In a recent article published by the New England Journal of Medicine, a 15-year Danish cohort study assessed the risk of thrombotic stroke and myocardial infarction associated with the hormonal contraception. Data was collected from nonpregnant women, ages 15 to 49 without a history of cancer or cardiovascular disease. Oral contraceptives that contained 30 to 40 µg ethinyl estradiol increased the risk of thrombotic stroke and myocardial infarction by a factor of 1.3 to 2.3 (specifically, 1.6 ((1.2 to 2.2) and 1.7 (1.0 to 2.6) for the progestin drospirenone). Of the 3311 women with their first thrombotic stroke, 1633 events were cerebral infarctions and 1678 were cerebral apoplexy. Fatalities occurred to 34 women with thrombotic strokes and 186 women with myocardial infarctions either during the primary event or a subsequent hospital stay. The study noted that while venous thrombosis is more likely than arterial thrombosis among young women, arterial thrombosis is associated with higher mortality rates and more serious consequences for survivors.

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